Assay Guidance Workshop for High-Throughput Screening and Lead Discovery

Tue Oct 18, 10:00 AM - Wed Oct 19, 5:30 PM (EDT)
NIH Main Campus, Building 35A  

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About the Workshop

The NCATS Assay Guidance Manual (AGM) is hosting a two-day workshop that will cover a broad range of critical concepts underlying assay development and implementation for high-throughput screening and lead discovery projects. This workshop is designed to disseminate critical information about the implementation of robust assay methods and is particularly relevant for researchers developing molecular probes or clinical candidates. Many of the workshop instructors have 20 to 30 years of experience in the field of drug discovery and will share information not readily found in a classroom or published material outside of the AGM. It will also cover emerging technologies and modalities in drug discovery, including the use of stem cells, antibody therapeutics, DNA-encoded libraries and advances in COVID-19 therapeutics.

This workshop will provide participants with a broad, practical perspective on assay development and data analysis so they can improve research projects involving drug discovery and know where to find further information; identify reagents, methods and instrumentation that are well suited to robust assays; and develop robust assays and the required counter and secondary assays for targets of interest. In addition, the workshop will provide participants with broad overviews and practical perspectives on new and emerging modalities in drug discovery.


Agenda



Download the agenda



About the Assay Guidance Manual

The Assay Guidance Manual (AGM) is a free, best-practices online resource devoted to the successful development of robust, early-stage drug discovery assays.

The manual was originally developed to provide step-by-step guidance based on experiential knowledge from drug developers for planning and executing projects in high-throughput screening, lead optimization and early phases of drug development. The AGM has now been expanded into a unique, user-friendly collection of over 50 chapters of well-tested knowledge, much of which is being documented for the first time. Methods outlined in the manual address appropriate statistical ways to analyze assay results and accommodate minor changes to assay protocols to ensure robustness.

Investigators worldwide can use the manual to design biologically and pharmacologically relevant assays for high-throughput screening and lead optimization to evaluate collections of molecules that modulate the activity of biological targets, pathways and cellular phenotypes.

The National Center for Advancing Translational Sciences (NCATS) manages the content of the manual with input from industry, academia and government experts. More than 100 authors from around the world have contributed content to this free resource, which is updated regularly and housed by the National Library of Medicine. The chapters have PubMed citations for the contributing authors.

Workshop Organizing Committee

Kyle Brimacombe, NCATS

Abigail Grossman, NCATS

Matthew Hall, NCATS

Sarine Markossian, NCATS

EVENT LOCATION

National Institutes of Health
Porter Neuroscience Building
35 Convent Drive
Building 35
Bethesda, MD 20892

The workshop will be held in Building 35, the Porter Neuroscience Building. There is no visitor parking near Building 35. We recommend visitors come through the NIH Visitor Gateway Center (see below) and either walk to Building 35 (approx. 15 minutes, 0.75 miles) or take the internal NIH shuttle bus to the building.

Once in Building 35, proceed to the conference rooms on the ground floor.

NIH VISITOR INFORMATION

NIH Campus Access and Security

Visitor Gateway Center Map

NIH Campus Map

Campus Dining Services




NCATS

Douglas Auld

Sr. Investigator I, Novartis Institutes for Biomedical Research

Joe Trask

Product Line Leader & Senior Application Scientist, Cellular Imaging and Analysis, Americas PerkinElmer

Marc Ferrer

Director, 3D Tissue Bioprinting Laboratory, NCATS

Michelle Arkin

Professor of Pharmaceutical Chemistry, University of California, San Francisco

Nathan P. Coussens, Ph.D.

Director, Molecular Pharmacology Branch Laboratories, Frederick National Laboratory for Cancer Research

Rosalia Gonzales

Director of Compound Management & Distribution, Pfizer

Sam Hoare

Founder Pharmechanics, LLC

Sarine Markossian

Editor-in-Chief, Assay Guidance Manual; Lead, Translational Science Resources Program, NCATS

Terry Riss

Scientific Ambassador, Cell Health Promega Corporation

Thomas D.Y. Chung

Director, Translational Programs Outreach, Conrad Prebys Center for Chemical Genomics at Sanford Burnham Prebys Medical Discovery Institute

Timothy L. Foley

Primary Pharmacology Group & DNA-Encoded Library Selection, Pfizer

Viswanath Devanarayan

Senior Statistics Director, GlaxoSmithKline

Xin Xu

Senior Scientist, NCATS

Yueming Wang

NIH Main Campus, Building 35A