NCATS Assay Guidance Workshop on Sample Management
About the Workshop
The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) program is hosting a half-day workshop that will cover a broad range of critical concepts, including practical approaches to, and best practices in, sample management. This workshop will also cover emerging technologies and trends in sample management, including novel platforms, and management of biologics, antisense oligonucleotides, natural products, and others. This workshop is organized in memory of our colleague, Paul Shinn, who passed away last fall. Paul was a foundational member of NCATS and its Division of Preclinical Innovation (DPI)’s compound management group leader.
Goals and Objectives
- Provide participants with fundamentals on sample management.
- Disseminate best practices in sample management.
- Introduce participants to emerging trends and technologies in sample management.
- Share experiences and seek practical advice about individual research concerns.
ZOOM LINK TBA
About the Assay Guidance Manual
The Assay Guidance Manual (AGM) is a free, best-practices online resource devoted to the successful development of robust, early-stage drug discovery assays.
The manual was originally developed to provide step-by-step guidance based on experiential knowledge from drug developers for planning and executing projects in high-throughput screening, lead optimization and early phases of drug development. The AGM has now been expanded into a unique, user-friendly collection of over 50 chapters of well-tested knowledge, much of which is being documented for the first time. Methods outlined in the manual address appropriate statistical ways to analyze assay results and accommodate minor changes to assay protocols to ensure robustness.
Investigators worldwide can use the manual to design biologically and pharmacologically relevant assays for high-throughput screening and lead optimization to evaluate collections of molecules that modulate the activity of biological targets, pathways and cellular phenotypes.
The National Center for Advancing Translational Sciences (NCATS) manages the content of the manual with input from industry, academia and government experts. More than 100 authors from around the world have contributed content to this free resource, which is updated regularly and housed by the National Library of Medicine. The chapters have PubMed citations for the contributing authors.
Workshop Organizing Committee
Kyle Brimacombe, NCATS
Abigail Grossman, NCATS
Rajarshi Guha, Vertex Pharmaceuticals
Matthew D. Hall, NCATS
Sarine Markossian, NCATS
Lesley Mathews, SLAS
Sam Michael, NCATS
Kelli Wilson, NCATS
This workshop was supported by the Intramural Research Program of the NCATS, NIH.
- Abigail Grossman